SOP for Cleaning of Paste Kettle
Standard Operating Procedure (SOP)
1. Objective
To describe the procedure for proper cleaning of the paste kettle to ensure removal of product residues and avoid contamination.
2. Scope
This SOP is applicable to the cleaning of the paste kettle used in the manufacturing area.
3. Responsibility
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Operator: To clean the equipment as per this SOP.
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Production Supervisor: To ensure compliance and proper documentation.
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QA Personnel: To verify the cleaning and release the equipment.
4. Materials and Equipment
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Purified water / WFI (as applicable)
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Approved cleaning agent (e.g., non-ionic detergent)
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Cleaning brushes (food/pharma grade)
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Lint-free cloth
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PPE (gloves, mask, goggles, apron)
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Logbook / Cleaning Record Sheet
5. Procedure
5.1 Pre-Cleaning Checks
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Ensure the paste kettle is switched off and unplugged.
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Allow the kettle to cool to room temperature before cleaning.
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Wear appropriate PPE.
5.2 Cleaning Steps (Product-to-Product or Daily Cleaning)
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Remove any remaining product or residue using a clean spatula.
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Rinse the inner surfaces with purified water to remove loose residue.
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Prepare a cleaning solution with approved detergent as per SOP.
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Scrub the internal and external surfaces using a soft brush and the cleaning solution.
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Rinse thoroughly with purified water until all detergent residues are removed.
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Wipe dry with a clean, lint-free cloth.
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Inspect visually to ensure cleanliness.
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If applicable, perform swab/rinse sampling for validation.
5.3 Final Rinse (if applicable)
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Use WFI (Water for Injection) or final rinse water as required for high-purity processes.
5.4 Cleaning After Batch or Periodic (Weekly/Monthly)
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Follow the same steps as daily cleaning with more detailed dismantling of parts like:
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Lid, agitator, outlet valve
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Inspect for wear and damage
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Clean and reassemble.
6. Post-Cleaning
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Affix a “Cleaned” status label with the date and time.
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Record the cleaning activity in the logbook or batch cleaning record.
7. Precautions
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Ensure no water enters electrical components.
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Avoid using abrasive materials that may damage surfaces.
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Always use approved cleaning agents.
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