Checklist for Vendor Audits

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Checklist for Vendor Audits

Vendor Audit Checklist

1. General Information

  • Vendor profile and organization structure available.

  • Valid licenses, registrations, and certifications (GMP, ISO, GDP).

  • Regulatory inspection history (FDA, EMA, WHO, local authorities).

  • Change notification procedure in place.

  • Approved supplier agreement/contract signed.

2. Quality Management System (QMS)

  • Documented Quality Policy and QMS in place.

  • SOPs available, current, and controlled.

  • Internal audit program implemented with CAPAs.

  • Management review meetings conducted with records.

  • Deviation, CAPA, and change control procedures established.

3. Facilities & Premises

  • Adequate facility design (segregated areas, unidirectional flow).

  • Cleanliness, housekeeping, and pest control records.

  • Environmental monitoring records (temperature, humidity, differential pressure).

  • Utilities validated (water, compressed air, HVAC).

  • Safety measures and emergency preparedness plans.

4. Equipment & Calibration

  • Equipment qualification (IQ/OQ/PQ) records.

  • Preventive maintenance schedules implemented.

  • Calibration program established and up to date.

  • Equipment cleaning and line clearance SOPs.

  • Equipment logbooks maintained.

5. Raw Material Management

  • Approved supplier list for critical raw materials and excipients.

  • Material receipt, quarantine, approval, and rejection process.

  • Sampling areas designed as per GMP requirements.

  • Storage conditions monitored and controlled.

  • Traceability maintained for all incoming raw materials.

6. Production & Process Control

  • Batch Manufacturing Records (BMR) available and reviewed.

  • Process validation and cleaning validation data.

  • In-process control checks documented.

  • Cross-contamination prevention measures implemented.

  • Yield reconciliation performed at each stage.

7. Quality Control Laboratory

  • Analytical method validation and verification records.

  • Equipment calibration and qualification records.

  • Stability studies data available (if applicable).

  • Handling of OOS/OOT and deviation investigations.

  • Data integrity controls (audit trails, ALCOA+ compliance).

8. Documentation & Data Integrity

  • Controlled documentation system in place.

  • Record retention policies established.

  • Data integrity practices aligned with FDA/EMA guidance.

  • Electronic system compliance with 21 CFR Part 11.

  • Training on GDP/GMP for staff.

9. Training & Personnel

  • Training records available for employees.

  • Job descriptions and competency assessments documented.

  • GMP, GDP, and safety training conducted.

  • Personnel hygiene and medical fitness maintained.

10. Distribution & Supply Chain

  • Packaging and labeling controls in place.

  • Shipping conditions monitored (temperature-sensitive products).

  • Traceability of shipments maintained.

  • Returned/rejected/recalled products handled as per SOP.

  • Contracted logistics service providers qualified.

11. Regulatory & Compliance

  • Vendor compliant with applicable GMP, GDP, and pharmacopoeial requirements.

  • Records of regulatory inspections and responses available.

  • No history of data falsification, fraud, or blacklisting.

  • Regulatory submissions updated (DMFs, CEPs, etc.).

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