by Dr. Yashashwini Reddy | Aug 11, 2025
Calibration of Hardness Tester in Pharmaceuticals 1. Introduction Tablet hardness testers are used in pharmaceutical QC labs to measure the crushing strength of tablets, which affects packaging, transport, and dissolution. Regular calibration ensures reliable and...
by Dr. Yashashwini Reddy | Aug 11, 2025
Calibration of Vernier Caliper 1. Introduction A Vernier Caliper is a precision measuring instrument used to measure internal dimensions, external dimensions, and depths. Calibration ensures measurement accuracy within specified tolerances, critical in quality control...
by Dr. Yashashwini Reddy | Aug 10, 2025
QC Audit Checklist 1. General Documentation & Records SOPs for all QC activities (latest approved versions, controlled copies). Records of training, competency assessments, and analyst qualification. QC logbooks (instrument usage, calibration, maintenance). Change...
by Dr. Yashashwini Reddy | Aug 10, 2025
Handling of Out of Calibration (OOC) Instruments and Equipment Definition Out of Calibration (OOC) refers to an instrument or equipment that, during calibration verification, fails to meet the specified acceptance criteria or shows results outside its defined...
by Dr. Yashashwini Reddy | Aug 9, 2025
Limitations in Dissolution Testing Poor In-Vivo Correlation (IVIVC) Dissolution data may not accurately predict drug release in the human body due to complex gastrointestinal (GI) conditions. Single-Media Testing Conventional USP tests often use only one dissolution...
