by Dr. Yashashwini Reddy | Aug 9, 2025
Limitations in Dissolution Testing Poor In-Vivo Correlation (IVIVC) Dissolution data may not accurately predict drug release in the human body due to complex gastrointestinal (GI) conditions. Single-Media Testing Conventional USP tests often use only one dissolution...
by Dr. Yashashwini Reddy | Aug 9, 2025
Working Principle of a pH Meter Definition A pH meter is an analytical instrument used to measure the hydrogen ion concentration ([H⁺]) in a solution, expressing it as pH (potential of hydrogen). Principle A pH meter works on the electrochemical principle of measuring...
by Dr. Yashashwini Reddy | Aug 9, 2025
Different Types of HPLC Detectors 1. UV/Vis Absorbance Detector Principle: Measures absorbance of analytes at a specific wavelength (Beer-Lambert Law). Types: Fixed Wavelength UV (e.g., 254 nm) Variable Wavelength UV Diode Array Detector (DAD/PDA) – allows spectral...
by Dr. Yashashwini Reddy | May 1, 2025
Validation and Calibration of Melting Point Instruments Introduction The melting point of a substance is a critical physical property used to identify and characterize chemicals, particularly in the pharmaceutical and chemical industries. For accurate and reproducible...
by Dr. Yashashwini Reddy | May 1, 2025
The calibration of automatic potentiometric titrators ensures the accuracy and reliability of titration results. This process involves verifying and adjusting the performance of the electrode system, burette system, and software against known standards. Below is a...
